Project Objectives

In order to accomplish SysKid’s aims the following subordinate objectives are defined:

Objective 1:
Integrate existing, and extend clinically well-defined sample cohorts of patients with chronic kidney disease.

Objective 2:
Establish and unify a broad ‘omics’ repository characterizing CKD.

Objective 3:
Decipher processes, molecular pathways and associated CKD biomarkers utilizing a Systems Biology approach.

Objective 4:
Use cell cultures and animal models to deepen our understanding of identified processes associated with early CKD.

Objective 5:
Delineate novel therapeutic strategies and pre-clinical evaluation for prevention and slowing of progression of chronic renal disease.

Objective 6:
Clinical validation of identified biomarkers for generating early stage diagnosis and prognosis IVD kits.

Objective 7:
Delineate a novel risk score for the development of chronic kidney disease.

Objective 8:
Deepen our understanding of the epidemiological aspects of early CKD with particular focus on consequences for healthcare policies.