Graduations

SysKid indeed offers a fruitful and stimulating environment for young researchers, with all the opportunities of cross-discipline activities in translational clinical research. We congratulate Merel Hellemons (University Medical Center Groningen) for obtaining her doctor degree!

“Merel Hellemons (Alkmaar, 1985) studied medicine in Groningen. She conducted her research at the departments of Clinical Pharmacology and Nephrology at the University Medical Center Groningen.. Her PhD thesis was conducted within the SysKid consortium financed by the EU.

Merel’s work out of SysKid:

1) ME Hellemons, J Kerschbaum, SJL Bakker et.al. Validity of biomarkers predicting onset or progression of nephropathy in patients wity type 2 diabetes: a systematic review. Diabetic Medicine 2012 29(5):567-77

2) ME Hellemons, M Mazagova, RT Gansevoort Growth Differentation Factor-15 predicts worsening of albuminuria in patients with type 2 diabetes Diabetes Care 2012 (In Press)

3) ME Hellemons, HJ Lambers Heerspink, RT Gansevoort High sensitivity troponin predicts worsening of albuminuria in Hypertension: Results of a Nested Case-Control study with confirmation in Diabetes: Journal of Hypertension provisionally accepted for publication

4) ME Hellemons, F Persson, SJL Bakker et.al. Initial ARB induced decrease in albuminuria is associated with long term renal outcome in type 2 diabetic patients with microalbuminuria: a Post-hoc analysis of the IRMA-2 trial Diabetes Care 2011 34(9) 2078-83

5) ME Hellemons, P Denig, D de Zeeuw et.al. Albuminuria screening and treatment in type 2 diabetes in primary care: Observational study of the GIANTT cohort. Submitted

top

FEATURING SYSKID: THE LATEST PAPERS

Follow our featured SysKid publications and 6 questions to the authors about their work:

MalaCards: an integrated compendium for diseases and their annotation.
Rappaport N, Nativ N, Stelzer G, Twik M, Guan-Golan Y, Iny Stein T, Bahir I, Belinky F, Morrey CP, Safran M, Lancet D.
Database (Oxford). 2013 Apr 12;2013(0):bat018

Q&A

1. What do you like most regarding your findings?

We like the fact that MalaCards serves not only an intellectual and research challenge but also a growing need of the community for a unifying resource of diseases.

» read more

The enzymatic activity of the VEGFR2 receptor for the biosynthesis of dinucleoside polyphosphates.

Jankowski V, Schulz A, Kretschmer A, Mischak H, Boehringer F, van der Giet M, Janke D, Schuchardt M, Herwig R, Zidek W, Jankowski J.
J Mol Med (Berl). 2013 May 1. [Epub ahead of print]

Q&A

1. What do you like most regarding your findings?

The physiological and pathophysiological impact of dinucleoside polyphosphates for example on vascular tone (1-3), proliferation rate of VSMC and endothelial cells (4-8), vascular calcification (9) as well as hemodynamic regulation of the renal system has been described in a large number of studies in recent years. However, the endogenous synthesis was still unknown. The knowledge of the endogenous synthesis is highly relevant since dinucleoside polyphosphates are new target for both hypertension and CKD. Therefore we are glad to have clarified the biosynthesis of dinucleoside polyphosphates recently.

» read more

MORE TO KNOW

» read our newsletter

» webcast: SME success story in FP7, SYSKID

» demo video: watch the SysKid molecular data integration concept

» flyer: download our information folder

MEET US

Stay in touch with the scientists of the SysKid team and find all upcoming events where you can meet members of the SysKid consortium, or relevant meetings in the field of nephrology or systems biology.

» More