FEATURING SYSKID: THE LATEST PAPERS

Follow our featured SysKid publications and 6 questions to the authors about their work:

MalaCards: an integrated compendium for diseases and their annotation.
Rappaport N, Nativ N, Stelzer G, Twik M, Guan-Golan Y, Iny Stein T, Bahir I, Belinky F, Morrey CP, Safran M, Lancet D.
Database (Oxford). 2013 Apr 12;2013(0):bat018

Q&A

1.    What do you like most regarding your findings?

We like the fact that MalaCards serves not only an intellectual and research challenge but also a growing need of the community for a unifying resource of diseases.

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The enzymatic activity of the VEGFR2 receptor for the biosynthesis of dinucleoside polyphosphates.

Jankowski V, Schulz A, Kretschmer A, Mischak H, Boehringer F, van der Giet M, Janke D, Schuchardt M, Herwig R, Zidek W, Jankowski J.
J Mol Med (Berl). 2013 May 1. [Epub ahead of print]

Q&A

1.    What do you like most regarding your findings?

The physiological and pathophysiological impact of dinucleoside polyphosphates for example on vascular tone (1-3), proliferation rate of VSMC and endothelial cells (4-8), vascular calcification (9) as well as hemodynamic regulation of the renal system has been described in a large number of studies in recent years. However, the endogenous synthesis was still unknown. The knowledge of the endogenous synthesis is highly relevant since dinucleoside polyphosphates are new target for both hypertension and CKD. Therefore we are glad to have clarified the biosynthesis of dinucleoside polyphosphates recently.

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