SysKid, a large-scale integrating European research project, aims at deepening our understanding of chronic kidney disease. The project paves the way for progress in prevention, new diagnostic strategies and treatment options for declining kidney function, which affects millions of patients suffering from diabetes and hypertension.


Follow our featured SysKid publications and 6 questions to the authors about their work:

Progression of renal injury toward interstitial inflammation and glomerular sclerosis is dependent on abnormal protein filtration

*Carlamaria Zoja1, *Mauro Abbate1  and  Giuseppe Remuzzi1,2 1IRCCS-Istituto di Ricerche Farmacologiche “Mario Negri”, Centro Anna Maria Astori, Bergamo, Italy and 2Unit of Nephrology and Dialysis, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy *equally contributed

Nephrol Dial Transplant. 2014 Aug 2. pii: gfu261. [Epub ahead of print]


1.    What do you like most regarding your findings?

Our group has been involved since many years in studying the role of  proteinuria in progressive renal injury. The present paper gave us the opportunity to review the current knowledges on mechanisms and mediators of interstitial inflammation and fibrosis in chronic proteinuric glomerulopathies to envisage potential targets for pharmacological interventions using combined therapies.

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From molecular signatures to predictive biomarkers: modeling disease pathophysiology and drug mechanism of action

Andreas Heinzel,  Paul Perco,  Gert Mayer,  Rainer Oberbauer,  Arno Lukas and  Bernd Mayer

Front. Cell Dev. Biol., 22 August 2014 | doi: 10.3389/fcell.2014.00037


1.    What do you like most regarding your findings?

SysKid enabled us embedding an end-to-end conceptual approach on integrating disease pathophysiology, drug mechanism of action and biomarkers. After a series of publications on specific peculiarities of such approach we finally integrated all in a feasible procedure for bringing precision medicine forward, exemplified on diabetic nephropathy.

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The relationship between estimated sodium and potassium excretion and subsequent renal outcomes.

Smyth A, Dunkler D, Gao P, Teo KK, Yusuf S, O'Donnell MJ, Mann JF, Clase CM.

Kidney Int. 2014 Jun 11. [Epub ahead of print]


1.    What do you like most regarding your findings?

Although our findings related primarily to surrogate outcomes (change in eGFR or proteinuria) rather than hard clinical endpoints (including dialysis), our findings are robust with little difference in the observed association across each outcome. Similarly, the associations were consistent when comparing the two different statistical methodologies (fractional polynomials which explores for non-linear associations, and the analyses comparing intakes in thirds). Taken together, this enhances the validity of our findings.

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» demo video: watch the SysKid molecular data integration concept

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Stay in touch with the scientists of the SysKid team and find all upcoming events where you can meet members of the SysKid consortium, or relevant meetings in the field of nephrology or systems biology.

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